The Impact of Iranian Propolis on Diabetes: A Randomized Double-Blind Clinical Trial

A groundbreaking study conducted by scholars at Ahvaz Jundishapur University of Medical Sciences in Iran has shed light on the potential benefits of Iranian propolis in managing type 2 diabetes. This randomized double-blind clinical trial evaluated the effects of propolis on glucose metabolism, lipid distribution, insulin resistance, kidney and liver function, and inflammatory biomarkers in patients with type 2 diabetes .

Study Details

The study, which took place from September 2017 to March 2018, involved 100 participants diagnosed with type 2 diabetes, aged between 35 and 85 years. Participants were not on insulin treatment, had no severe liver or kidney dysfunction, and had a diabetes history of no more than 10 years. They were randomly divided into two groups: one receiving propolis and the other a placebo .

Propolis Intervention

The propolis group consumed Iranian propolis capsules (500 mg twice daily), while the placebo group received capsules identical in appearance. The intervention lasted for 90 days, with no changes to the participants’ diet or exercise routines. Measurements were taken at the start and after 90 days .

Significant Findings

1. Improvement in Glucose Metabolism and Insulin Resistance: Compared to the placebo group, the propolis group experienced an average decrease of 8% in glycated hemoglobin, 28.6% in 2-hour postprandial blood glucose, and 50.8% in insulin levels. However, there was no significant difference in fasting blood glucose between the two groups. The propolis group’s glycated hemoglobin decreased by an average of 0.98% over 90 days, with insulin levels dropping by as much as 45% .
2. Improvement in Lipid Metabolism: The propolis group showed a significant increase of 10.6% in high-density lipoprotein (HDL) compared to the placebo group. However, there were no significant differences in total cholesterol, low-density lipoprotein (LDL), triglycerides, and very-low-density lipoprotein (VLDL) between the two groups. The propolis group’s HDL increased by 9.5% over 90 days .
3. Improvement in Kidney and Liver Function: The propolis group had significantly lower concentrations of liver transaminases (ALT and AST) and blood urea nitrogen (BUN) .
4. Anti-inflammatory Effects: The propolis group experienced a significant decrease of 60.43% in C-reactive protein and 49.6% in tumor necrosis factor-alpha (TNF-α) compared to the placebo group .

Conclusion

In conclusion, Iranian propolis has shown beneficial effects in reducing postprandial blood glucose, insulin, insulin resistance, and inflammatory cytokines, particularly in glucose metabolism and insulin resistance. These findings suggest that propolis could be a valuable addition to the management of type 2 diabetes .

Final Thoughts

The integration of natural remedies like Iranian propolis into diabetes treatment protocols may offer a complementary approach for patients seeking to improve their glycemic control and overall health. It is essential to consult with healthcare professionals before incorporating propolis or any supplement into a diabetes management plan.